2-Oleamido-1,3-Octadecanediol

INCI: 2-OLEAMIDO-1,3-OCTADECANEDIOL

A skin-conditioning agent that supports barrier function in acne-focused skincare formulations

Best For Skin Types

All, Acne-prone, Sensitive

Addresses

Acne, Sensitivity, Dryness

Usage Frequency

Daily

What Is 2-Oleamido-1,3-Octadecanediol?

2-Oleamido-1,3-octadecanediol is a synthetic skin-conditioning agent derived from oleic acid, a naturally occurring fatty acid. It belongs to a class of ingredients designed to support the skin's outer layers and maintain hydration.

In skincare formulations, this ingredient works to condition and soften the skin whilst helping to maintain moisture balance. It is typically used in specialist treatments targeting acne-prone skin, where it may help counterbalance the drying effects of active acne-fighting ingredients.

How It Works

2-Oleamido-1,3-octadecanediol functions as an emollient and conditioning agent. Its molecular structure allows it to sit on or within the outer layers of the skin, helping to trap moisture and create a softer skin surface.

In multi-ingredient acne formulations, its conditioning properties may help offset the potential dryness and irritation caused by active acne-fighting components such as salicylic acid or benzoyl peroxide, promoting better tolerance to treatment.

Clinical Evidence & References

Limited standalone research exists for this ingredient. However, it appears in clinical studies of multi-targeted acne formulations. In one randomised trial comparing a salicylic acid-based cream containing this ingredient (alongside niacinamide, lipohydroxy acid, and other actives) against benzoyl peroxide 5%, the combination formulation showed comparable efficacy for mild to moderate acne whilst potentially offering better tolerability.

Evidence is currently limited to its role within complex formulations rather than as an isolated agent. Further research would help clarify its specific contribution to acne management and its effects across different skin types.

How to Use

This ingredient is typically found in pre-formulated acne treatments rather than standalone products. Use as directed by the product instructions, usually applied twice daily. Allow other active ingredients in the formulation to do the primary work whilst this ingredient supports skin comfort and hydration throughout treatment.

Safety & Precautions

Generally well-tolerated in skincare formulations. As with any skincare product, discontinue use if irritation develops and perform a patch test if you have sensitive skin.

How widely it's used

0.2%
of skincare products contain this ingredient .
Most common in: Moisturisers

Regulatory information

Standardised cosmetic-ingredient identifiers used by regulators.

Show identifiers
INCI Name
2-OLEAMIDO-1,3-OCTADECANEDIOL
Function
Skin Conditioning

Learn More About Skincare Ingredients

Explore our comprehensive ingredient glossary to understand what's in your products.

Browse All Ingredients

Authorised Stockist

Official UK retailer

Tracked Delivery

Free UK shipping over £50

5 Star Rating

Trusted by thousands

Expert Advice

Free consultations