Acetyl Hexapeptide-51 Amide
INCI: ACETYL HEXAPEPTIDE-51 AMIDE
Also known as: Acetyl Hexapeptide-51 Amide
A peptide that conditions skin with a mechanism still being understood by researchers
At a glance
Best For Skin Types
All
Addresses
Effective Concentrations
Up to 0.005%
Usage Frequency
Daily
What Is Acetyl Hexapeptide-51 Amide?
Acetyl Hexapeptide-51 Amide is a synthetic peptide—a short chain of amino acids—designed for use in skincare formulations. Peptides are smaller than proteins and are used in cosmetics primarily for their skin conditioning properties, helping to support the skin's texture and appearance.
This particular hexapeptide functions as a skin conditioning agent in cosmetic products. Like other peptides in this category, it is used at very low concentrations in finished formulations.
How It Works
Acetyl Hexapeptide-51 Amide works as a conditioning agent, meaning it helps to support the skin's surface properties and overall feel. The exact biological mechanisms of action for this specific peptide variant remain an area of ongoing research.
Peptides in skincare generally function by providing amino acid building blocks that support skin health, though the degree to which topically applied peptides penetrate the skin barrier and affect deeper layers is still being investigated.
Clinical Evidence & References
Research on acetyl hexapeptides in cosmetics is limited. Safety assessments have established that related hexapeptides (such as Acetyl Hexapeptide-8) are safe for cosmetic use at very low concentrations. However, specific efficacy data for Acetyl Hexapeptide-51 Amide is not widely published in accessible scientific literature.
The evidence base for what this ingredient actually delivers in terms of measurable skin benefits remains unclear. It is positioned as a conditioning agent rather than an active treatment ingredient, so expectations should be calibrated accordingly.
How to Use
Acetyl Hexapeptide-51 Amide is typically incorporated into serums, creams, and moisturisers at very low levels. It can be used daily as part of a standard skincare routine. Since peptides are generally well-tolerated, there is no reason to limit frequency unless you are using multiple peptide-containing products and wish to simplify your routine.
Safety & Precautions
Regulatory information
Standardised cosmetic-ingredient identifiers used by regulators.
Show identifiers
- INCI Name
- ACETYL HEXAPEPTIDE-51 AMIDE
- Function
- Skin Conditioning
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