Acetyl Sh-Decapeptide-2 Amide
INCI: ACETYL SH-DECAPEPTIDE-2 AMIDE
Also known as: Acetyl Sh-decapeptide-2 Amide
A peptide derivative that conditions and supports skin's structural integrity
At a glance
Best For Skin Types
All
Addresses
Usage Frequency
Daily
What Is Acetyl Sh-Decapeptide-2 Amide?
Acetyl Sh-Decapeptide-2 Amide is a synthetic peptide — a short chain of amino acids — designed to function as a skin conditioning agent. Peptides in skincare are valued for their small molecular size, which allows them to penetrate the outer layers of skin relatively easily compared to larger proteins.
This particular peptide works primarily as a conditioning ingredient, helping to improve skin texture and support the skin's natural barrier function. It is typically used in concentrations small enough to be compatible with a range of formulations.
How It Works
As a peptide, this ingredient works by interacting with skin cells to reinforce structural proteins and support hydration mechanisms. Peptides are thought to signal to skin cells, encouraging them to maintain or strengthen key functions like barrier integrity and moisture retention.
The 'Acetyl' component of its name indicates a chemical modification that enhances stability and skin penetration, allowing the peptide to work more effectively within the skin.
Clinical Evidence & References
Research on this specific ingredient is limited in the published literature. The broader peptide category has demonstrated conditioning and structural support benefits, but direct clinical studies on Acetyl Sh-Decapeptide-2 Amide itself are not readily available in peer-reviewed sources.
Related peptides in the acetyl decapeptide family have been assessed for safety in cosmetic use, with guidance suggesting safe use at low concentrations. If you are considering this ingredient for a specific skin concern, it is worth consulting the formulation as a whole, as conditioning benefits are often most pronounced when combined with complementary ingredients.
How to Use
As a conditioning agent, this peptide works best as part of a layered routine. Apply it in serums, moisturisers, or essences after cleansing and any active treatments, then follow with a broad-spectrum sunscreen during the day. There is no need for special timing or rotation; it can be used daily as part of your standard skincare protocol.
Safety & Precautions
Regulatory information
Standardised cosmetic-ingredient identifiers used by regulators.
Show identifiers
- INCI Name
- ACETYL SH-DECAPEPTIDE-2 AMIDE
- Function
- Skin Conditioning
Learn More About Skincare Ingredients
Explore our comprehensive ingredient glossary to understand what's in your products.
Browse All IngredientsShop Our Products
Find professional skincare solutions at Skintique.