Acetyl Sh-Tripeptide-4 Amide

INCI: ACETYL SH-TRIPEPTIDE-4 AMIDE

Also known as: Acetyl Sh-tripeptide-4 Amide

A peptide derivative designed to condition and support skin comfort

At a glance

Peptide

Best For Skin Types

All, Sensitive, Dry

Addresses

Sensitivity, Dryness, Barrier repair

Usage Frequency

Daily

What Is Acetyl Sh-Tripeptide-4 Amide?

Acetyl Sh-Tripeptide-4 Amide is a synthetic peptide—a short chain of amino acids modified with an acetyl group. Peptides in skincare are derived from or designed to mimic naturally occurring protein fragments that can interact with skin cells.

This ingredient functions primarily as a skin conditioning agent, meaning it is used to improve the texture, appearance, and overall feel of the skin when applied topically.

How It Works

Peptides like this one are believed to interact with skin cells and may support the skin's natural processes. The acetyl modification may enhance how the peptide behaves in formulations and how it penetrates or interacts with the skin.

However, the specific mechanism by which this particular tripeptide works is not extensively documented in published research, so the details of how it delivers its conditioning benefits remain somewhat unclear.

Clinical Evidence & References

Published clinical evidence specifically for Acetyl Sh-Tripeptide-4 Amide is limited. Related peptide ingredients, such as Acetyl Hexapeptide-8 Amide, have been assessed for safety in cosmetics at specified concentrations, suggesting the peptide family is generally regarded as suitable for skincare use.

To understand this ingredient's efficacy, longer-term and more detailed studies would be beneficial. Current evidence supports its use as a conditioning agent rather than demonstrating dramatic or measurable changes to skin appearance.

How to Use

This ingredient is typically included in formulations at low concentrations as part of a broader skincare formula. It works best as part of a consistent routine alongside other evidence-backed ingredients targeted to your specific skin concerns. Apply as directed on the product label—usually daily as part of your moisturiser or treatment serum.

Safety & Precautions

Peptides are generally well-tolerated in skincare. This ingredient is not known to cause irritation in most people, though those with very sensitive skin should patch test first.

Regulatory information

Standardised cosmetic-ingredient identifiers used by regulators.

Show identifiers
INCI Name
ACETYL SH-TRIPEPTIDE-4 AMIDE
Function
Skin Conditioning

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