Acetyl Tetrapeptide-18
INCI: ACETYL TETRAPEPTIDE-18
Also known as: Acetyl Tetrapeptide-18
A peptide that supports skin's natural repair and conditioning processes
At a glance
Best For Skin Types
All, Dry, Sensitive, Mature
Addresses
Usage Frequency
Daily
What Is Acetyl Tetrapeptide-18?
Acetyl Tetrapeptide-18 is a synthetic peptide—a short chain of amino acids—designed to mimic natural signalling molecules in the skin. Peptides function as messengers that communicate with skin cells, encouraging them to maintain their structural integrity and perform their essential functions.
This ingredient works primarily as a skin conditioning agent, helping to support the skin's barrier function and overall resilience. It is typically used in formulations where maintaining skin hydration and softness is a priority.
How It Works
Peptides like Acetyl Tetrapeptide-18 communicate with skin cells by binding to receptors on their surface. This signalling prompts cells to produce and maintain structural proteins and lipids that form the skin barrier—the outermost layer responsible for keeping moisture in and irritants out.
By supporting the skin's natural lipid production and barrier integrity, this peptide helps maintain hydration levels and skin resilience, which are foundational to healthy skin appearance and function.
Clinical Evidence & References
Research into acetyl-CoA metabolism and skin barrier function suggests that acetylation processes—the addition of acetyl groups—play an important role in regulating lipid synthesis in both the epidermis and sebaceous glands. This indicates that ingredients targeting these pathways may support barrier health and skin conditioning.
However, direct clinical studies specifically demonstrating the efficacy of Acetyl Tetrapeptide-18 in human skin are limited in the available literature. The ingredient appears in skincare formulations primarily for its skin conditioning role, though more robust evidence would strengthen claims about its specific benefits.
Published Research
How to Use
Acetyl Tetrapeptide-18 is typically found in serums, moisturisers, and barrier-repair products. It can be used daily as part of a regular skincare routine. It pairs well with other hydrating and conditioning ingredients, and is generally suitable for layering with other actives, though it is not itself considered a treatment-strength active.
Safety & Precautions
Regulatory information
Standardised cosmetic-ingredient identifiers used by regulators.
Show identifiers
- INCI Name
- ACETYL TETRAPEPTIDE-18
- EC Number
- -
- Function
- Skin Conditioning
Learn More About Skincare Ingredients
Explore our comprehensive ingredient glossary to understand what's in your products.
Browse All IngredientsShop Our Products
Find professional skincare solutions at Skintique.