Acetyl Tetrapeptide-22
INCI: ACETYL TETRAPEPTIDE-22
Also known as: Acetyl Tetrapeptide-22
A peptide that supports skin's natural conditioning and resilience
At a glance
Best For Skin Types
All, Dry, Mature, Sensitive
Addresses
Usage Frequency
Daily
What Is Acetyl Tetrapeptide-22?
Acetyl tetrapeptide-22 is a synthetic peptide — a short chain of amino acids — designed to support skin conditioning. Peptides in skincare work by signalling to skin cells, potentially influencing how they behave and maintain their structural integrity.
This particular peptide is used in formulations primarily for its skin-conditioning properties, helping to maintain skin's texture and overall appearance.
How It Works
Peptides are recognised by skin cells as signalling molecules. Acetyl tetrapeptide-22 is believed to communicate with fibroblasts and other skin cells, potentially influencing their production of structural proteins and their response to stress.
The acetyl group (a chemical modification) may also play a role in how the peptide interacts with skin cells and how effectively it penetrates or remains in the skin.
Clinical Evidence & References
Research into peptides generally supports their role in skin signalling and conditioning. The mechanism of action — influencing acetyl-CoA metabolism and cellular processes — aligns with broader evidence around how cells regulate protein synthesis and stress responses.
However, specific clinical studies directly evaluating acetyl tetrapeptide-22's efficacy in finished skincare products are limited in the published literature. Most evidence comes from mechanistic studies and ingredient supplier data rather than independent human trials.
Published Research
How to Use
Acetyl tetrapeptide-22 is typically found in serums, moisturisers and treatments. Use as directed on product packaging. It tends to work well in layered routines, particularly alongside other conditioning or barrier-supporting ingredients. Results develop gradually with consistent use over several weeks.
Safety & Precautions
Regulatory information
Standardised cosmetic-ingredient identifiers used by regulators.
Show identifiers
- INCI Name
- ACETYL TETRAPEPTIDE-22
- EC Number
- -
- Function
- Skin Conditioning
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