Acetyl Tetrapeptide-9
INCI: Dermican, Replexium, Cosroma AT-9
Also known as: Dermican, Replexium, Cosroma AT-9
Signal peptide” with anti-ageing benefits Supports skin’s firmness and elasticity
Best For Skin Types
All skin types
Usage Frequency
As directed on product packaging
EWG Safety Score
What Is Acetyl Tetrapeptide-9?
Acetyl tetrapeptide-9 is a “signal peptide” used in skin care for its anti-ageing benefits. It works by supporting key skin components like collagen, glycosaminoglycans (GAGs), and lumican, which are essential for maintaining skin structure and elasticity. Studies indicate topical application improves skin density and firmness, for a smoother, more taut appearance.
This peptide is also touted for its hydrating and plumping effects. It is lab-engineered through a process known as acetylation (a chemical reaction that involves transforming tetrapeptide-9 into an effective agent for skin). Tetrapeptide-9 is composed of the amino acids aspartic acid, glutamine, histidine and valine.
Benefits for Your Skin
How It Works
Clinical Evidence & References
Published Research
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Acetyl Tetrapeptide-9: Collagen synthesis support Molecules, 2019
Related Ingredients
Acetyl Dipeptide-1 Cetyl Ester
Lab-made anti-ageing peptide that promotes firmer skin Bio-identical to a skin-natural peptide that aids elasticity
Acetyl Glycyl Beta-Alanine
Peptide for reducing skin redness and sensitivity
Acetyl Hexapeptide-1
A synthetic peptide Composed of the amino acids
Acetyl Hexapeptide-37
Synthetic peptide Composed of amino acids (alanine, proline, serine, and glycine)
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