Acetylsalicyloyl Pentapeptide-33
INCI: ACETYLSALICYLOYL PENTAPEPTIDE-33
Also known as: Acetylsalicyloyl Pentapeptide-33
A peptide-salicylate hybrid designed to protect skin from oxidative stress
At a glance
Best For Skin Types
All
Addresses
Usage Frequency
Daily
What Is Acetylsalicyloyl Pentapeptide-33?
Acetylsalicyloyl Pentapeptide-33 is a synthetic ingredient that combines a salicylate moiety (derived from aspirin chemistry) with a short chain of amino acids known as a pentapeptide. This hybrid structure is designed to offer both antioxidant and skin-protective properties in a single molecule.
The ingredient functions primarily as an antioxidant, helping to neutralise free radicals and reduce oxidative stress on the skin. It is used in skincare formulations at relatively low concentrations to support the skin's natural defences against environmental damage.
Benefits for Your Skin
How It Works
The ingredient works through its antioxidant capacity. Free radicals are unstable molecules generated by UV exposure, pollution and natural cellular processes. Antioxidants like this one donate electrons to neutralise these radicals, reducing their potential to damage skin proteins and cells. The peptide structure may also interact with skin cells in ways that support their resilience to oxidative stress.
Clinical Evidence & References
Research into acetylsalicyloyl derivatives suggests that this class of compound can penetrate the skin and exert antioxidant effects in vitro. However, specific clinical studies demonstrating the efficacy of acetylsalicyloyl pentapeptide-33 in living skin are limited in the published literature.
The ingredient appears in skincare products marketed for antioxidant and protective benefits, but substantiation of real-world performance in human skin would benefit from further investigation. It is generally recognised as a safe cosmetic ingredient when used at typical concentrations.
How to Use
This ingredient is typically found in serums, moisturisers and treatment products where it works alongside other actives. It can generally be used daily as part of a morning or evening routine. It integrates well with other antioxidants and does not typically require special application technique. If combining with other actives, apply lighter textures first.
Safety & Precautions
Regulatory information
Standardised cosmetic-ingredient identifiers used by regulators.
Show identifiers
- INCI Name
- ACETYLSALICYLOYL PENTAPEPTIDE-33
- Function
- Antioxidant, Skin Protecting
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