Best For Skin Types
All skin types
Effective Concentrations
0.5-2%
Usage Frequency
As directed on product packaging
EWG Safety Score
What Is Allantoin?
Allantoin is a byproduct of uric acid that can be extracted from urea and is the result of metabolic processes that occur in most organisms - among them animals (including humans) and bacteria. It can also be extracted from comfrey (taken from the roots and leaves) and is proven safe and effective because it does not contain the potentially irritating alkaloid compounds that occur in the comfrey plant.
Despite the natural source of allantoin being safe, the type of allantoin used in skin care products is generally produced synthetically as this guarantees no impurities while sacrificing none of allantoin’s effectiveness. It serves as an effective soothing agent and has moisturizing properties, giving it value especially in products designed to treat sensitive or compromised skin. It can also help mitigate skin’s response to stronger active ingredients and is often included in formulas to help buffer any potential adverse effects.
In cosmetics, it is used in concentrations up to 2%, but in clinical settings it can be used in greater amounts, where research has shown it can have an impact on healing. In the United States, it is FDA-approved as an over the counter (OTC) skin protectant in concentrations of 0.5-2%.
Benefits for Your Skin
How It Works
Clinical Evidence & References
- Chemistry Series, March 2020, pages 7-21
- Molecules, June 2019, pages 1-33
- European Journal of Pharmacology, February 2018, pages 68-78
- Journal of the American Academy of Dermatology, June 2017, Volume 76, Issue 2, Supplement 1
- Pharmacognosy Review, Volume 5, July-December 2011
- International Journal of Toxicology, May 2010, Supplement, pages 84S-97S
- Journal of Occupational Medicine and Toxicology, October 2008, ePublication
- https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=347&showFR=1
Published Research
-
Allantoin as a skin protectant in dermatology Dermatology, 1999
How to Use
Safety & Precautions
Related Ingredients
Adenosine
Helps improve the visible appearance of wrinkles Has soothing properties
Albatrellus Confluens (Mushroom) Extract
Source of antioxidants that promote youthful-looking skin Has a pronounced soothing effect on skin
Aloe Barbadensis
Time-honoured botanical for soothing and hydration
Aloe Barbadensis Leaf Juice Extract
Concentrated aloe extract for enhanced skin benefits
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