Aluminum Sesquichlorohydrate
INCI: ALUMINUM SESQUICHLOROHYDRATE
An aluminium salt that reduces sweat production by blocking sweat gland ducts
Best For Skin Types
All
Addresses
Effective Concentrations
10-25%
Usage Frequency
2-3 times per week (after initial 1-2 week nightly phase)
What Is Aluminum Sesquichlorohydrate?
Aluminium sesquichlorohydrate is an inorganic salt derived from aluminium chloride. It functions as an antiperspirant rather than a deodorant, meaning it works to reduce the volume of sweat produced rather than simply masking odour. The ingredient is commonly used in concentrations between 10% and 25% in antiperspirant formulations.
When applied to the skin, it creates a physical barrier that partially blocks eccrine sweat gland ducts, thereby decreasing sweat secretion at the source. Because antiperspirants inherently reduce moisture on the skin's surface, they also prevent the bacterial breakdown of sweat that causes odour.
How It Works
Aluminium sesquichlorohydrate undergoes hydrolysis when it contacts moisture on the skin, releasing aluminium ions. These ions form a plug-like complex within the sweat gland duct, physically obstructing the flow of sweat to the skin surface. This mechanism is distinct from deodorants, which mask or neutralise odour rather than preventing perspiration.
Because this hydrolysis process is acidifying, formulations typically include emollients and pH regulators to minimise irritation and maintain skin comfort during regular use.
Clinical Evidence & References
Clinical trials support the efficacy of aluminium sesquichlorohydrate for managing both axillary (underarm) and palmar hyperhidrosis. Research comparing 20% aluminium sesquichlorohydrate with 20% aluminium chloride showed both formulations were effective at reducing sweating intensity, with comparable efficacy profiles.
Primary irritant contact dermatitis is a recognised side effect of aluminium salt treatments. Newer foam formulations have been developed to improve tolerability by reducing residue and skin irritation. However, broader questions about systemic aluminium safety and long-term health outcomes remain subject to scientific debate, and consumers should be aware that evidence on these concerns is not conclusive.
Published Research
How to Use
Apply aluminium sesquichlorohydrate products to clean, dry skin, typically at night before bed to allow maximum contact time with sweat glands. Initial protocols often involve nightly application for 1–2 weeks, followed by a maintenance schedule of 2–3 times per week. If irritation develops, reduce frequency or discontinue use and allow the skin to recover. Formulations designed with lower residue or foam bases may be gentler if you have sensitive skin.
Safety & Precautions
Regulatory information
Standardised cosmetic-ingredient identifiers used by regulators.
Show identifiers
- INCI Name
- ALUMINUM SESQUICHLOROHYDRATE
- INN Name
- aluminium sesquichlorohydrate
- EC Number
- 234-310-4
- Function
- Antiperspirant, Astringent, Deodorant
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