Arginine/Lysine Polypeptide

INCI: ARGININE/LYSINE POLYPEPTIDE

Also known as: Arginine/lysine Polypeptide

A peptide blend that supports skin structure and hydration

At a glance

Peptide

Best For Skin Types

All, Dry, Mature

Addresses

Fine lines, Dryness, Hydration

Usage Frequency

Daily

What Is Arginine/Lysine Polypeptide?

Arginine/lysine polypeptide is a short-chain protein fragment composed of amino acids—specifically arginine and lysine—that are building blocks naturally found in skin. This ingredient is created through the breakdown of larger proteins into smaller peptide chains, making them small enough to penetrate the skin's outer layers.

In skincare formulations, it functions as a skin conditioning agent, working to support the skin's natural moisture retention and structural integrity. Peptides like this one are used because they mimic components of collagen and elastin, the proteins responsible for skin firmness and elasticity.

How It Works

Arginine and lysine are amino acids that play key roles in collagen synthesis and skin structure. When delivered as a polypeptide, they can penetrate the outer skin layers and provide raw material for the skin's natural protein production processes.

The mechanism relies on the skin recognising these amino acid building blocks and incorporating them into its own structural proteins. This supports the skin's natural repair and maintenance functions, particularly important as collagen naturally degrades over time.

Clinical Evidence & References

Evidence for arginine/lysine polypeptides in skincare remains limited. Research into bioactive peptide delivery systems suggests that peptide blends can support improvements in skin hydration, wrinkle appearance, and skin density when formulated effectively—particularly when combined with delivery technologies like microneedles. However, these studies typically examine multi-peptide formulations rather than this ingredient in isolation.

The amino acids themselves (arginine and lysine) are established as important to collagen metabolism, but translating this into consumer skincare benefits requires further research specific to topical application and absorption rates in finished products.

How to Use

This ingredient works best as part of a multi-step routine. Apply to cleansed skin morning and evening, or according to product instructions. Since peptides work gradually to support skin structure, consistent use over weeks is more beneficial than intermittent application. Layer with hydrating ingredients like hyaluronic acid to enhance moisture retention.

Safety & Precautions

Arginine/lysine polypeptide is generally well-tolerated across skin types. Those with sensitivities to amino acids or peptide-based products should patch test first.

How widely it's used

0.1%
of skincare products contain this ingredient .
Most common in: Treatments Moisturisers

Regulatory information

Standardised cosmetic-ingredient identifiers used by regulators.

Show identifiers
INCI Name
ARGININE/LYSINE POLYPEPTIDE
EC Number
-
Function
Skin Conditioning

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