Argireline
INCI: Acetyl Hexapeptide-8
Also known as: Acetyl Hexapeptide-3, Acetyl Hexapeptide-8
The expression line relaxer
Best For Skin Types
All skin types
Addresses
Effective Concentrations
5-10%
Usage Frequency
As directed on product packaging
EWG Safety Score
What Is Argireline?
Argireline (acetyl hexapeptide-3 or acetyl hexapeptide-8) is a synthetic peptide designed to reduce the appearance of expression lines and wrinkles. Often referred to as topical Botox, it works by relaxing facial muscle contractions without the need for injections.
Argireline interferes with the SNARE complex, which is essential for muscle contraction. By inhibiting this complex, it reduces the intensity of facial muscle movements that cause dynamic wrinkles, particularly around the forehead and eyes.
While Argireline is not as powerful as Botox injections, clinical studies have shown it can reduce wrinkle depth by up to 30% with consistent use over 30 days. It works best on expression lines caused by repeated facial movements.
Argireline is most effective at concentrations of 5-10% and works well when combined with other peptides and hydrating ingredients. Apply to areas prone to expression lines.
Benefits for Your Skin
Clinical Evidence & References
This ingredient is backed by moderate clinical research supporting its effectiveness.
Published Research
-
Argireline: an antiwrinkle peptide International Journal of Cosmetic Science, 2002
-
Anti-aging efficacy of acetyl hexapeptide-8 (Argireline) Journal of Cosmetic and Laser Therapy, 2013
How to Use
Safety & Precautions
Related Ingredients
Acetyl Dipeptide-1 Cetyl Ester
Lab-made anti-ageing peptide that promotes firmer skin Bio-identical to a skin-natural peptide that aids elasticity
Acetyl Glycyl Beta-Alanine
Peptide for reducing skin redness and sensitivity
Acetyl Hexapeptide-1
A synthetic peptide Composed of the amino acids
Acetyl Hexapeptide-37
Synthetic peptide Composed of amino acids (alanine, proline, serine, and glycine)
Learn More About Skincare Ingredients
Explore our comprehensive ingredient glossary to understand what's in your products.
Browse All IngredientsShop Our Products
Find professional skincare solutions at Skintique.