Oligopeptide-3
Also known as: Creapep ®
Peptide made up of several amino acids | Manufacturers claim it boosts skin’s resilience
Addresses
EWG Safety Score
What Is Oligopeptide-3?
Oligopeptide-3 is a synthetic (lab-engineered) peptide made up of the amino acids alanine, lysine, phenylalanine, and tridecapeptide with leucine.
Manufacturers of oligopeptide-3, also known by the trade name Creapep ®, claim it binds with skin cell receptors to trigger increases of elastin, hyaluronic acid, and factors that increase skin resilience to fight visible signs of aging.
While there isn’t yet a breadth of independent, peer-reviewed research backing some of these claims, peptides are hydrating and skin conditioning ingredients that do help improve the look and feel of skin.
The recommended use level of oligopeptide-3 in skin care products is 0.01–0.1%, which speaks to the potency of this peptide and its affinity for skin.
Benefits for Your Skin
Clinical Evidence & References
Published Research
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ULProspector, Website, Accessed August 2025 [https://www.ulprospector.com/en/eu/PersonalCare/Detail/126262/7083850/Creapep-Oligopeptide-3]
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SpecialChem, Website, Accessed August 2025 [https://www.specialchem.com/cosmetics/product/tidetronbio-creapep-oligopeptide-3]
Related Ingredients
Acetyl Dipeptide-1 Cetyl Ester
Lab-made anti-ageing peptide that promotes firmer skin Bio-identical to a skin-natural peptide that aids elasticity
Acetyl Glycyl Beta-Alanine
Peptide for reducing skin redness and sensitivity
Acetyl Hexapeptide-1
A synthetic peptide Composed of the amino acids
Acetyl Hexapeptide-37
Synthetic peptide Composed of amino acids (alanine, proline, serine, and glycine)
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